Additional benefits of vitamin B2 over other migraine treatments is that it is very cheap, hardly a positive contribution and side effects. Vitamin B2 plays a role in energy metabolism of body cells. It helps the mitochondria provide energy. When a power failure, a reaction can occur which leads to a migraine attack.

In a study of migraine, patients showed that a daily dose of 400 mg vitamin B2 three months after the migraine frequency decreased by 37%. It had little effect on the symptoms themselves. The effect was seen after one months and was taking up after three months

It appeared that a vitamin B2 supplementation works best in people who had a moderate form of migraine with a few attacks per Month The effect of vitamin B2, according to a Belgian study similar to drugs such as beta-blockers but without adverse side effects. 53 migraine sufferers were given a high daily doses of vitamin B2, riboflavin, or a placebo tablet to swallow. In 56% of users ribovlavine there was improvement in the number, severity and duration of migraine attacks. 19% of the placebo group had benefited.

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