The goal of treatment for substance is effective in reducing the frequency and intensity of migraine attacks. It is proposed where the seizures are frequent (from three per month) and/or disabling (with a significant impact on activities by their intensity or duration). The drugs most used are dihydroergotamine, propranolol (beta blocker), methysergide, the Flunarizine, sodium valproate and amitryptilline (Tricyclic antidepressant, effective especially if there is a component associated with depressive illness). Note that these products have been created for indications other than migraine at baseline (anti-epileptic, antidepressant etc)
One can also cite the indoramine (alpha blocker) as background therapy specific.
The molecule chosen must be taken regularly for 3 months, keeping a calendar of self-monitoring, containing the crisis with quote their intensity and their duration, taken medication, potential side effects, especially the efficiency. If effective, treatment is still taken 6 months before being gradually stopped hoping for a remission more or less complete and lasting crisis.
Today some of these treatments are sometimes associated with certain classes of anti-epileptic drugs including anti-migraine is now demonstrated.
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